Congenital fibrinogen deficiency

MONDO:0018060

Congenital deficiencies of fibrinogen are coagulation disorders characterized by bleeding symptoms ranging from mild to severe resulting from reduced quantity and/or quality of circulating fibrinogen. Afibrinogenemia (complete absence of fibrinogen) and hypofibrinogenemia (reduced plasma fibrinogen concentration) correspond to quantitative anomalies of fibrinogen while dysfibrinogenemia corresponds to a functional anomaly of fibrinogen. Hypo- and dysfibrinogenemia may be frequently combined (hypodysfibrinogenemia).

Also known as: congenital fibrinogen deficiency, fibrinogen deficiency, congenital

16 clinical trials for this condition and its sub-types, 2 tagged with Congenital fibrinogen deficiency itself.

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Where it sits in the disease tree

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Part of

↑ Hemorrhagic disease (510) ↑ Coagulation protein disease (274)

Sub-types of Congenital fibrinogen deficiency

Familial dysfibrinogenemia 2 trials · 6 incl. sub-types
1 sub-type
- Congenital afibrinogenemia 4 trials · 5 incl. sub-types Sub-types →

Most studied deeper sub-types

Familial hypofibrinogenemia (3) Familial hypodysfibrinogenemia (0)

Including sub-types (16) Tagged with Congenital fibrinogen deficiency (2)

Trials to join now! 1 Not yet recruiting 1

Can a 5-Minute blood test save trauma patients from unnecessary treatment?

Knowledge-focused Recruiting now

This study looks at whether a quick bedside test can measure fibrinogen levels in trauma patients with severe bleeding within minutes, instead of the usual 30-45 minutes. Fibrinogen helps blood clot, and low levels can worsen bleeding. The test is being checked for feasibility an…

Sponsor: Erasmus Medical Center • Aim: Knowledge-focused

Last updated Jun 27, 2026 09:03 UTC

Congenital fibrinogen deficiency

Where it sits in the disease tree

Most studied deeper sub-types

Can a 5-Minute blood test save trauma patients from unnecessary treatment?