Combined immunodeficiency due to DOCK8 deficiency
MONDO:0009478Combined immunodeficiency due to dedicator of cytokinesis 8 protein (DOCK8) deficiency is a form of T and B cell immunodeficiency characterized by recurrent cutaneous viral infections, susceptibility to cancer and elevated serum levels of immunoglobulin E (IgE).
Also known as: Cid due to DOCK8 deficiency, DOCK8 immunodeficiency syndrome, combined immunodeficiency due to DOCK8 deficiency, combined immunodeficiency due to dedicator of cytokinesis 8 protein deficiency, dedicator of cytokinesis 8 deficiency, AR hyperimmunoglobulin E syndrome, AR-HIES, DOCK8 deficiency
46 clinical trials for this condition and its sub-types, 6 tagged with Combined immunodeficiency due to DOCK8 deficiency itself.
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Stem cell transplant offers hope for rare immune disorder
Disease control OngoingThis study tests whether a stem cell transplant from a matched sibling, unrelated donor, or half-matched parent can fix the immune system in people with DOCK8 deficiency, a genetic condition that causes severe infections and cancer. Participants aged 4 to 35 receive chemotherapy …
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Scientists collect skin cells to pave way for future immune disease cures
Knowledge-focused By invitation onlyThis study collects small skin samples from people with primary immunodeficiency or immune regulation disorders, as well as from healthy volunteers. Researchers will use these cells to create cell lines for laboratory research. The goal is to better understand immune diseases and…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC