Cold agglutinin disease
MONDO:0018922Cold agglutinin disease is a type of autoimmune hemolytic anemia defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30B0C).
Also known as: CAD, CAS, chronic cold agglutinin disease, cold agglutinin syndrome, anemia, hemolytic, cold antibody, cold antibody disease, cold antibody hemolytic anaemia, cold antibody hemolytic anemia
58 clinical trials for this condition and its sub-types, 14 tagged with Cold agglutinin disease itself.
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Experimental drug iptacopan tested for rare blood disorders
Disease control Stopped earlyThis study tested an experimental drug called iptacopan in people with two rare blood disorders: immune thrombocytopenia (ITP) and cold agglutinin disease (CAD). The goal was to see if the drug could improve platelet counts in ITP or hemoglobin levels in CAD. The trial was termin…
Phase 2 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Experimental drug for rare blood disorder tested for long-term safety
Disease control Stopped earlyThis study tested the long-term safety of a drug called SAR445088 in people with cold agglutinin disease, a rare condition where the immune system attacks red blood cells. Only 9 participants were enrolled, and the study was terminated early. The goal was to see if the drug is sa…
Phase 1 • Sponsor: Bioverativ, a Sanofi company • Aim: Disease control
Last updated Jun 26, 2026 16:38 UTC