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Coagulation protein disease
MONDO:0002242Congenital or acquired deficiency of one of the coagulation factors. It results in bleeding.
Also known as: coagulation factor deficiency, coagulation factor deficiency syndrome
275 clinical trials for this condition and its sub-types, 13 tagged with Coagulation protein disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Coagulation protein disease
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Hemophilia 55 trials · 214 incl. sub-types
4 sub-types
- Hemophilia A 178 trials Sub-types →
- Hemophilia B 84 trials · 91 incl. sub-types Sub-types →
- Acquired hemophilia 2 trials · 7 incl. sub-types Sub-types →
- Factor XI deficiency 0 trials Sub-types →
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Von Willebrand disease (hereditary or acquired) 39 trials · 46 incl. sub-types
2 sub-types
- Hereditary von Willebrand disease 18 trials · 29 incl. sub-types Sub-types →
- Acquired von willebrand syndrome 3 trials
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Acquired coagulation factor deficiency 4 trials · 15 incl. sub-types
6 sub-types
- Acquired hemophilia 2 trials · 7 incl. sub-types Sub-types →
- Acquired von willebrand syndrome 3 trials
- Acquired factor X deficiency 1 trial
- Acquired factor V deficiency 0 trials
- Acquired factor VII deficiency 0 trials
- Acquired factor XIII deficiency 0 trials
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Factor VII deficiency 6 trials
2 sub-types
- Congenital factor VII deficiency 3 trials
- Acquired factor VII deficiency 0 trials
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Congenital fibrinogen deficiency 2 trials · 6 incl. sub-types
1 sub-type
- Familial dysfibrinogenemia 2 trials · 6 incl. sub-types Sub-types →
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Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types
5 sub-types
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Factor X deficiency 2 trials
2 sub-types
- Acquired factor X deficiency 1 trial
- Congenital factor X deficiency 0 trials
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Congenital factor XII deficiency 1 trial
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Hypoplasminogenemia 1 trial
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East Texas bleeding disorder 0 trials
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Tatsumi factor deficiency 0 trials
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Alpha-2-plasmin inhibitor deficiency 0 trials
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Dysplasminogenemia 0 trials
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Factor V amsterdam bleeding disorder 0 trials
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Factor V atlanta bleeding disorder 0 trials
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Factor V deficiency 0 trials
2 sub-types
- Acquired factor V deficiency 0 trials
- Congenital factor V deficiency 0 trials
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Factor XIII deficiency 0 trials
2 sub-types
- Acquired factor XIII deficiency 0 trials
- Congenital factor XIII deficiency 0 trials Sub-types →
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Inherited prekallikrein deficiency 0 trials
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Plasminogen deficiency, type II 0 trials
Most studied deeper sub-types
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One-Time gene therapy could free hemophilia patients from frequent infusions
Disease control OngoingThis study tests a one-time gene therapy (valoctocogene roxaparvovec) in 6 Japanese men with severe hemophilia A. The goal is to help their bodies produce their own clotting factor, reducing or stopping the need for regular factor VIII infusions. Participants will be monitored fo…
Phase 3 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Gene therapy for hemophilia a: how long does it last?
Disease control By invitation onlyThis study checks the long-term safety and effectiveness of a one-time gene therapy (BMN 270) for people with severe hemophilia A. Participants from earlier BioMarin trials will be followed for many years to see if the treatment continues to work and remains safe. The goal is to …
Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC