Coagulation protein disease

MONDO:0002242

Congenital or acquired deficiency of one of the coagulation factors. It results in bleeding.

Also known as: coagulation factor deficiency, coagulation factor deficiency syndrome

275 clinical trials for this condition and its sub-types, 13 tagged with Coagulation protein disease itself.

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Where it sits in the disease tree

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Part of

↑ Blood coagulation disease (539)

Sub-types of Coagulation protein disease

Hemophilia 55 trials · 214 incl. sub-types
4 sub-types
- Hemophilia A 178 trials Sub-types →
- Hemophilia B 84 trials · 91 incl. sub-types Sub-types →
- Acquired hemophilia 2 trials · 7 incl. sub-types Sub-types →
- Factor XI deficiency 0 trials Sub-types →
Von Willebrand disease (hereditary or acquired) 39 trials · 46 incl. sub-types
2 sub-types
- Hereditary von Willebrand disease 18 trials · 29 incl. sub-types Sub-types →
- Acquired von willebrand syndrome 3 trials
Acquired coagulation factor deficiency 4 trials · 15 incl. sub-types
6 sub-types
- Acquired hemophilia 2 trials · 7 incl. sub-types Sub-types →
- Acquired von willebrand syndrome 3 trials
- Acquired factor X deficiency 1 trial
- Acquired factor V deficiency 0 trials
- Acquired factor VII deficiency 0 trials
- Acquired factor XIII deficiency 0 trials
Factor VII deficiency 6 trials
2 sub-types
- Congenital factor VII deficiency 3 trials
- Acquired factor VII deficiency 0 trials
Congenital fibrinogen deficiency 2 trials · 6 incl. sub-types
1 sub-type
- Familial dysfibrinogenemia 2 trials · 6 incl. sub-types Sub-types →
Thrombophilia due to activated protein C resistance 5 trials
Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types
5 sub-types
- Congenital factor VII deficiency 3 trials
- Vitamin K-dependent clotting factors, combined deficiency of, type 1 1 trial
- Congenital factor X deficiency 0 trials
- Congenital prothrombin deficiency 0 trials
- Vitamin K-dependent clotting factors, combined deficiency of, type 2 0 trials
Factor X deficiency 2 trials
2 sub-types
- Acquired factor X deficiency 1 trial
- Congenital factor X deficiency 0 trials
Congenital factor XII deficiency 1 trial
Congenital plasminogen activator inhibitor type 1 deficiency 1 trial
Hypoplasminogenemia 1 trial
East Texas bleeding disorder 0 trials
Tatsumi factor deficiency 0 trials
Alpha-2-plasmin inhibitor deficiency 0 trials
Combined deficiency of factor V and factor VIII 0 trials
3 sub-types
Combined deficiency of factor VII and factor X 0 trials
Congenital high-molecular-weight kininogen deficiency 0 trials
Dysplasminogenemia 0 trials
Factor V amsterdam bleeding disorder 0 trials
Factor V atlanta bleeding disorder 0 trials
Factor V deficiency 0 trials
2 sub-types
- Acquired factor V deficiency 0 trials
- Congenital factor V deficiency 0 trials
Factor V short isoforms-related bleeding disorder 0 trials
Factor XIII deficiency 0 trials
2 sub-types
- Acquired factor XIII deficiency 0 trials
- Congenital factor XIII deficiency 0 trials Sub-types →
Hemorrhagic disease due to alpha-1-antitrypsin Pittsburgh mutation 0 trials
Inherited prekallikrein deficiency 0 trials
Multiple sclerosis-ichthyosis-factor VIII deficiency syndrome 0 trials
Plasminogen deficiency, type II 0 trials
Thrombomodulin-related bleeding disorder 0 trials

Most studied deeper sub-types

Severe hemophilia A (49) Severe hemophilia B (9) Von Willebrand disease 3 (9) Acquired hemophilia A (5) Congenital afibrinogenemia (4) Moderately severe hemophilia A (4) Von Willebrand disease 2 (4) Familial hypofibrinogenemia (3) Von Willebrand disease 1 (3) Mild hemophilia A (2) Moderately severe hemophilia B (2) Von Willebrand disease type 2A (2) Von Willebrand disease type 2N (2) Mild hemophilia B (1) Von Willebrand disease type 2B (1) Von Willebrand disease type 2M (1) Acquired factor XI deficiency (0) Acquired hemophilia B (0) Congenital factor XI deficiency (0) Factor XIII, A subunit, deficiency of (0)

Including sub-types (275) Tagged with Coagulation protein disease (13)

Trials to join now! 6 Not yet finished but already full! 2 Completed 5

Coagulation protein disease

Where it sits in the disease tree

Most studied deeper sub-types

One-shot gene therapy aims to free hemophilia patients from constant infusions

Weekly shot aims to get severe hemophilia patients moving more

One-Time gene therapy shows promise for hemophilia a

Real-World study tracks Alprolix's bleeding control in hemophilia b

New hemophilia drug may last longer, reducing need for frequent shots