CIC-rearranged sarcoma
MONDO:0956989An EWSERI-negative small round cell tumor that is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and either DUX4 gene on chromosome 4 or DUX4L gene on chromosome 10. The translocation results in either CIC-DUX4, t(4;19)(q35;q13) or CIC-DUX4L, t(10;19)(q26;q13) fusions.
2770 clinical trials for this condition and its sub-types, 5 tagged with CIC-rearranged sarcoma itself.
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New cocktail of cancer drugs shows promise for Tough-to-Treat sarcoma
Disease control OngoingThis study tests whether adding three drugs (vincristine, irinotecan, and regorafenib) to standard chemotherapy can help people with Ewing sarcoma that has spread. About 437 participants will receive either the new combo or standard treatment. The goal is to see if the new approa…
Phase 2/3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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New drug BTX-A51 tested in rare sarcomas
Disease control OngoingThis early study tests an oral drug called BTX-A51 in 24 people with advanced liposarcoma (a type of fat tissue cancer) that has spread or come back. The main goal is to see if the drug is safe and tolerable at different doses. It focuses on specific genetic subtypes: MDM2-amplif…
Phase 1 • Sponsor: Michael Wagner, MD • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC