CIC-rearranged sarcoma
MONDO:0956989An EWSERI-negative small round cell tumor that is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and either DUX4 gene on chromosome 4 or DUX4L gene on chromosome 10. The translocation results in either CIC-DUX4, t(4;19)(q35;q13) or CIC-DUX4L, t(10;19)(q26;q13) fusions.
2770 clinical trials for this condition and its sub-types, 5 tagged with CIC-rearranged sarcoma itself.
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Radical new schedule aims to cure High-Risk ewing sarcoma
Cure Recruiting nowThis study tests a new treatment schedule for people with metastatic Ewing sarcoma, a rare and aggressive cancer. The approach uses an intense first attack on cancer cells, followed by targeted strikes and long-term maintenance to wipe out remaining cells. The goal is a cure. The…
Phase 1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Cure
Last updated Sep 20, 2026 00:00 UTC
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Immune booster drug tested on rare cancers
Disease control Recruiting nowThis study is testing a drug called pembrolizumab in people with ultra-rare sarcomas, a group of very uncommon cancers. The drug works by releasing the immune system's brakes so it can attack cancer cells. Researchers want to see if it can shrink tumors or stop them from growing,…
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC