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CIC-rearranged sarcoma

MONDO:0956989

An EWSERI-negative small round cell tumor that is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and either DUX4 gene on chromosome 4 or DUX4L gene on chromosome 10. The translocation results in either CIC-DUX4, t(4;19)(q35;q13) or CIC-DUX4L, t(10;19)(q26;q13) fusions.

2770 clinical trials for this condition and its sub-types, 5 tagged with CIC-rearranged sarcoma itself.

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Where it sits in the disease tree

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Part of

↑ EWSR1-negative small round cell tumor (5)

Including sub-types (2770) Tagged with CIC-rearranged sarcoma (5)

Trials to join now! 2 Not yet finished but already full! 2 Completed 1

Cancer drug regorafenib tested to halt bone sarcoma spread

Disease control Completed

This phase 2 trial tests whether the drug regorafenib can stop or slow the growth of metastatic bone sarcomas (cancers that started in bone and spread). 163 patients with osteosarcoma, Ewing sarcoma, chondrosarcoma, or chordoma are randomly assigned to receive regorafenib or a pl…

Phase 2 • Sponsor: UNICANCER • Aim: Disease control

Last updated Jul 23, 2026 00:00 UTC