Chronic primary adrenal insufficiency
MONDO:0015129A chronic disorder of the adrenal cortex resulting in the inadequate production of glucocorticoid and mineralocorticoid hormones.
Also known as: CPAI, chronic adrenocorticoid insufficiency, hypoadrenocorticism, familial, primary adrenal insufficiency, chronic, primary hypoadrenalism, Addison disease, chronic adrenal insufficiency, adrenal aplasia, adrenal gland hypofunction
49 clinical trials for this condition and its sub-types, 6 tagged with Chronic primary adrenal insufficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Chronic primary adrenal insufficiency
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Congenital adrenal hyperplasia 36 trials · 38 incl. sub-types
8 sub-types
- Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 20 trials Sub-types →
- Classic congenital adrenal hyperplasia 5 trials
- Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency 1 trial
- Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency 1 trial
- Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency 1 trial
- Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency 1 trial
- Congenital lipoid adrenal hyperplasia due to STAR deficency 1 trial Sub-types →
- Non-classic congenital adrenal hyperplasia 0 trials
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Triple-A syndrome 3 trials
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1 sub-type
- Adrenal hypoplasia, cytomegalic type 0 trials
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Familial glucocorticoid deficiency 0 trials
6 sub-types
- Adrenocortical unresponsiveness to ACTH with postreceptor defect 0 trials
- Glucocorticoid deficiency 1 0 trials
- Glucocorticoid deficiency 2 0 trials
- Glucocorticoid deficiency 3 0 trials
- Glucocorticoid deficiency 4 0 trials
- Glucocorticoid deficiency 5 0 trials
Most studied deeper sub-types
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Music therapy from home: a new hope for autoimmune and depression?
Symptom relief Recruiting nowThis study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…
Sponsor: Appalachian State University • Aim: Symptom relief
Last updated Aug 01, 2026 00:00 UTC
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Rare disease mystery: can tracking SPLIS patients unlock its secrets?
Knowledge-focused Recruiting nowThis study follows people with SPLIS, a rare inherited metabolic condition, to map its natural history—how the disease unfolds over time. Researchers will track growth, organ function, quality of life, and survival in about 28 participants. The goal is to understand the full rang…
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Aug 06, 2026 00:00 UTC
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New registry aims to unlock secrets of Ultra-Rare SPLIS disease
Knowledge-focused Recruiting nowThis study collects medical and genetic information from people with SPLIS, a rare condition caused by a faulty enzyme. Researchers will track survival and when kidney problems start. No treatments are given, but the registry may help future research.
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC