Chronic primary adrenal insufficiency

MONDO:0015129

A chronic disorder of the adrenal cortex resulting in the inadequate production of glucocorticoid and mineralocorticoid hormones.

Also known as: CPAI, chronic adrenocorticoid insufficiency, hypoadrenocorticism, familial, primary adrenal insufficiency, chronic, primary hypoadrenalism, Addison disease, chronic adrenal insufficiency, adrenal aplasia, adrenal gland hypofunction

49 clinical trials for this condition and its sub-types, 6 tagged with Chronic primary adrenal insufficiency itself.

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Where it sits in the disease tree

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↑ Primary adrenal insufficiency (48)

Sub-types of Chronic primary adrenal insufficiency

Congenital adrenal hyperplasia 36 trials · 38 incl. sub-types
8 sub-types
Triple-A syndrome 3 trials
X-linked adrenal hypoplasia congenita 0 trials
1 sub-type
- Adrenal hypoplasia, cytomegalic type 0 trials
Adrenocortical hypofunction, chronic primary congenital 0 trials
Autoimmune primary adrenal insufficiency 0 trials
Familial adrenal hypoplasia with absent pituitary luteinizing hormone 0 trials
Familial glucocorticoid deficiency 0 trials
6 sub-types
- Adrenocortical unresponsiveness to ACTH with postreceptor defect 0 trials
- Glucocorticoid deficiency 1 0 trials
- Glucocorticoid deficiency 2 0 trials
- Glucocorticoid deficiency 3 0 trials
- Glucocorticoid deficiency 4 0 trials
- Glucocorticoid deficiency 5 0 trials
Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency 0 trials

Most studied deeper sub-types

Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, salt wasting form (0) Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form (0) Classic congenital lipoid adrenal hyperplasia due to STAR deficency (0) Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency (0)

Including sub-types (49) Tagged with Chronic primary adrenal insufficiency (6)

Trials to join now! 3 Not yet recruiting 1 Not yet finished but already full! 1 Completed 1

Do some Addison's patients still make their own hormones? new study investigates.

Knowledge-focused Ongoing

This study looks at how many people with Addison's disease still produce small amounts of adrenal hormones like cortisol, even years after diagnosis. Researchers will test 200 adults in Norway and Sweden using blood and urine samples. The goal is to see if this leftover function …

Sponsor: University of Bergen • Aim: Knowledge-focused

Last updated Jun 27, 2026 12:30 UTC

Chronic primary adrenal insufficiency

Where it sits in the disease tree

Most studied deeper sub-types

Do some Addison's patients still make their own hormones? new study investigates.