Chronic lymphoproliferative disorder of NK-cells
MONDO:0004234An Epstein-Barr virus negative disorder with a chronic clinical course affecting predominantly adults and characterized by the proliferation of large granular lymphocytes with natural killer cell immunophenotype. The T-cell receptor genes are not rearranged.
Also known as: CLPD-NK, CNKL, NK-LGL leukaemia, NK-LGL leukemia, NK-LGLL, NK-cell large granular lymphocyte lymphocytosis, NK-cell lineage granular lymphocyte proliferative disorder, NK-type lymphoproliferative disorder of granular lymphocytes
1849 clinical trials for this condition and its sub-types, 4 tagged with Chronic lymphoproliferative disorder of NK-cells itself.
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New hope for rare blood cancers: targeted drug trial opens
Disease control Recruiting nowThis study tests a drug called golidocitnib in people with slow-growing but hard-to-treat T/NK-cell lymphomas that have not responded to standard therapy. The goal is to see if the drug can shrink or control the cancer. About 48 adults will take the drug by mouth, and researchers…
Phase 2 • Sponsor: Institute of Hematology & Blood Diseases Hospital, China • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Old drug, new hope? thalidomide trial targets rare leukemia
Disease control Recruiting nowThis phase 2 trial tests thalidomide, a drug once used for other conditions, in 48 people with symptomatic large granular lymphocytic (LGL) leukemia. Participants start on thalidomide alone; if it doesn't work well enough, methotrexate is added. The goal is to see if thalidomide …
Phase 2 • Sponsor: Institute of Hematology & Blood Diseases Hospital, China • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Massive T-Cell lymphoma database aims to unlock new insights
Knowledge-focused Recruiting nowThis study is creating a large database of information and tissue samples from 1,000 people with T-cell lymphoma. Researchers will use this data to learn more about the disease and how to improve patient outcomes. Participants provide medical information and optional blood and na…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Massive new registry to track thousands of blood cancer patients for years
Knowledge-focused Recruiting nowThis study is a registry that will follow up to 8,000 people with chronic lymphocytic leukemia (CLL) and related blood cancers over many years. It does not test a new treatment but instead collects information on how patients are doing over time, including survival. The goal is t…
Sponsor: German CLL Study Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC