Chandler syndrome

MONDO:0020369

Chandler syndrome, the most frequent clinical variant of iridocorneal endothelial (ICE) syndrome, is characterized by very few iris abnormalities but more severe corneal edema and less severe secondary glaucoma than seen in the other two ICE syndrome variants: Cogan-Reese syndrome and essential iris atrophy.

Also known as: Chandler's Syndrome, Chandler's syndrome, endothelial corneal dystrophy

8 clinical trials for this condition and its sub-types, 2 tagged with Chandler syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Corneal dystrophy (60) ↑ Iridocorneal endothelial syndrome (3)

Including sub-types (8) Tagged with Chandler syndrome (2)

Not yet recruiting 1 Completed 1

One shot to see clearly: cell therapy takes on corneal edema

Cure Not yet recruiting

This phase 2 trial tests whether a single injection of EO2002, made from magnetic human corneal endothelial cells, can safely improve vision in people with corneal edema caused by endothelial dysfunction. Participants receive either a low or high dose of cells or a placebo inject…

Phase 2 • Sponsor: Emmecell • Aim: Cure

Last updated Jul 31, 2026 00:00 UTC

Chandler syndrome

Where it sits in the disease tree

One shot to see clearly: cell therapy takes on corneal edema