Central sleep apnea syndrome
MONDO:0004731A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health.
Also known as: central sleep apnea syndrome, central sleep apnea, primary, primary central sleep apnea, secondary central sleep apnea, Apneas, central, Apneas, central sleep, Breathings, central sleep-disordered, alveolar hypoventilation, central
64 clinical trials for this condition and its sub-types, 21 tagged with Central sleep apnea syndrome itself.
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Browse by category →Sub-types of Central sleep apnea syndrome
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Complex sleep apnea 1 trial
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Drug induced central sleep apnea 1 trial
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Primary central sleep apnea syndrome 0 trials
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AI listens to the diaphragm to spot breathing pauses in premature babies
Diagnosis Not yet recruitingThis study tests whether a machine-learning model can automatically detect pauses in breathing, called apnoea, in preterm infants born before 32 weeks of gestation. The model uses signals from the diaphragm muscle, along with airway pressure and oxygen levels, recorded over eight…
Sponsor: King's College Hospital NHS Trust • Aim: Diagnosis
Last updated Sep 02, 2026 00:00 UTC
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Will jaw surgery breathing problems fix themselves? new study aims to find out
Knowledge-focused Not yet recruitingThis study follows 60 adults who had jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Some develop central or mixed sleep apneas after surgery, and researchers want to see if these breathing issues get better, stay the same, or get worse over a year. Parti…
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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New study aims to crack the code on Hard-to-Treat sleep apnea in heart failure
Knowledge-focused Not yet recruitingThis study looks at why people with heart failure or those taking opioid painkillers develop central sleep apnea (pauses in breathing during sleep). Current treatments don't work well, so researchers will test combinations of breathing machines and medications in 200 Veterans. Th…
Phase 4 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC