Central sleep apnea syndrome
MONDO:0004731A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health.
Also known as: central sleep apnea syndrome, central sleep apnea, primary, primary central sleep apnea, secondary central sleep apnea, Apneas, central, Apneas, central sleep, Breathings, central sleep-disordered, alveolar hypoventilation, central
64 clinical trials for this condition and its sub-types, 21 tagged with Central sleep apnea syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central sleep apnea syndrome
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Complex sleep apnea 1 trial
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Drug induced central sleep apnea 1 trial
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Primary central sleep apnea syndrome 0 trials
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Remote monitoring may boost sleep apnea therapy adherence
Disease control CompletedThis study follows over 14,000 adults with sleep apnea who are prescribed positive airway pressure (PAP) therapy. It investigates whether using telemonitoring—where the device sends usage data to their doctor remotely—helps people use the therapy more consistently and effectively…
Sponsor: ResMed • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Could a home device spot sleep apnea in people on narcotics?
Diagnosis CompletedThis study tests whether a wearable home sleep apnea device called WatchPAT200 can accurately detect central sleep apnea in people who take narcotic medications. Participants wear the device during an overnight lab sleep study, and results are compared to the standard in-lab test…
Sponsor: Kaiser Permanente • Aim: Diagnosis
Last updated Jul 22, 2026 00:00 UTC
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Sleep therapy shows promise for veterans battling PTSD and insomnia
Symptom relief CompletedThis study tested a behavioral sleep treatment in 36 veterans who have PTSD, insomnia, and sleep apnea. The goal was to see if improving sleep also improves quality of life and daily functioning. Participants attended therapy sessions and reported their sleep and well-being throu…
Phase 2 • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Could a common pill replace CPAP for opioid users?
Symptom relief CompletedThis study tested whether the drug acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either the drug or a placebo for one week each. The goal was to see if the pill could reduce sleep apnea events as an alternat…
Phase 2 • Sponsor: University of California, San Diego • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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French study tracks sleep quality in central apnea patients using smart ventilator
Knowledge-focused CompletedThis study followed 520 French adults with central or mixed sleep apnea to see how a treatment called adaptive servo-ventilation (ASV) improved their sleep quality. Participants used a breathing device that adjusts pressure in real time. The goal was to measure changes in sleep q…
Sponsor: Société Française de Recherche et de Médecine du Sommeil • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Tiny study explores better lead placement for sleep apnea device
Knowledge-focused CompletedThis small study tested whether placing a nerve stimulation lead in a different spot during a sleep apnea device implant could improve breathing. 29 adults with moderate to severe central sleep apnea took part. The goal was to see immediate changes in breathing and airway functio…
Sponsor: Respicardia, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC