Central nervous system germ cell tumor
MONDO:0003000A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.
Also known as: CNS germ cell neoplasm, CNS germ cell tumor, CNS germ cell tumour, central nervous system germ cell neoplasm, central nervous system germ cell tumor, central nervous system rare germ cell tumor, central nervous system rare germ cell tumour, germ cell neoplasm of CNS
1458 clinical trials for this condition and its sub-types, 6 tagged with Central nervous system germ cell tumor itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system germ cell tumor
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Central nervous system germinoma 2 trials · 4 incl. sub-types
3 sub-types
- Brain germinoma 1 trial · 4 incl. sub-types Sub-types →
- Childhood central nervous system germinoma 1 trial Sub-types →
- Adult central nervous system germinoma 0 trials
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Malignant pineal area germ cell neoplasm 2 trials · 3 incl. sub-types
5 sub-types
- Pineal region germinoma 3 trials
- Pineal region immature teratoma 1 trial
- Pineal region yolk sac tumor 1 trial
- Pineal region choriocarcinoma 0 trials
- Pineal region dysgerminoma 0 trials
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4 sub-types
- Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
- Central nervous system teratoma 0 trials · 1 incl. sub-types Sub-types →
- Choriocarcinoma of the central nervous system 0 trials Sub-types →
- Embryonal carcinoma of the central nervous system 0 trials Sub-types →
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Childhood central nervous system germ cell tumor 0 trials · 2 incl. sub-types
8 sub-types
- Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
- Childhood central nervous system germinoma 1 trial Sub-types →
- Childhood central nervous system embryonal carcinoma 0 trials
- Childhood central nervous system immature teratoma 0 trials
- Childhood central nervous system mature teratoma 0 trials
- Childhood central nervous system mixed germ cell tumor 0 trials
- Childhood germ cell brain tumor 0 trials
- Pediatric CNS choriocarcinoma 0 trials
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5 sub-types
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2 sub-types
Most studied deeper sub-types
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Tailored treatment may reduce radiation side effects in young brain tumor patients
Disease control Recruiting nowThis phase 2 trial tests a personalized approach for children and young adults with a rare brain tumor called non-germinomatous germ cell tumor (NGGCT). Patients first receive chemotherapy, and then the type and amount of radiation they get depends on how well the tumor responds.…
Phase 2 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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New chemo cocktail aims to tackle rare brain tumors
Disease control Recruiting nowThis phase 2 trial is testing a combination of two chemotherapy drugs, teniposide and cisplatin, in 40 people newly diagnosed with central malignant germ cell tumors. The goal is to see if the combo is safe and effective at shrinking tumors and prolonging survival. Researchers wi…
Phase 2 • Sponsor: Chengcheng Guo • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC