CDKL5 disorder

MONDO:0100039

A monogenic disease that has material basis in mutation in the CDKL5 gene.

Also known as: CDKL5 Deficiency Disorder, CDKL5 disorder, CDKL5 inherited genetic disease, inherited genetic disease caused by mutation in CDKL5, CDKL5, CDKL5-related disorder

11 clinical trials for this condition and its sub-types, 8 tagged with CDKL5 disorder itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary disease (18187)

Sub-types of CDKL5 disorder

Developmental and epileptic encephalopathy, 2 10 trials

Including sub-types (11) Tagged with CDKL5 disorder (8)

Not yet recruiting 2 Not yet finished but already full! 2 Completed 3 Terminated 1

New drug shows promise for Tough-to-Treat seizures in kids

Disease control Stopped early

This study looked at the long-term safety of soticlestat, an experimental drug, in children and adults with severe forms of epilepsy like Dravet syndrome and Lennox-Gastaut syndrome. Participants took soticlestat twice a day along with their usual seizure medicines. The study was…

Phase 2 • Sponsor: Takeda • Aim: Disease control

Last updated Sep 06, 2026 00:00 UTC

CDKL5 disorder

Where it sits in the disease tree

New drug shows promise for Tough-to-Treat seizures in kids