C3 glomerulonephritis

MONDO:0013892

Glomerulonephritis characterized by C3 accumulation with little or absent deposition of immunoglobulin, in the absence of ultrastructural electron-dense transformation seen in dense deposit disease.

Also known as: complement-mediated membranoproliferative glomerulonephritis, nephropathy due to CFHR5 deficiency, CFHR5 deficiency

11 clinical trials for this condition and its sub-types, 7 tagged with C3 glomerulonephritis itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary nephritis (152) ↑ Complement 3 glomerulopathy (24)

Including sub-types (11) Tagged with C3 glomerulonephritis (7)

Trials to join now! 2 Not yet recruiting 1 Not yet finished but already full! 2 Completed 2

New injection shows promise for kidney disease patients

Disease control Not yet recruiting

This study tests an investigational drug called LP-005 in 46 adults with complement-mediated kidney disease, a condition where the immune system attacks the kidneys. Participants receive the injection alongside their standard care. The goal is to see if the drug can reduce protei…

Phase 2 • Sponsor: Longbio Pharma • Aim: Disease control

Last updated Jun 27, 2026 08:13 UTC

C3 glomerulonephritis

Where it sits in the disease tree

New injection shows promise for kidney disease patients