B-cell prolymphocytic leukemia

MONDO:0019461

A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly.

Also known as: B prolymphocytic leukaemia, B prolymphocytic leukemia, B-PLL, B-cell prolymphocytic leukemia, BPLL

2019 clinical trials for this condition and its sub-types, 7 tagged with B-cell prolymphocytic leukemia itself.

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Where it sits in the disease tree

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Part of

↑ Neoplasm of mature B-cells (2704) ↑ Aggressive B-cell non-Hodgkin lymphoma (1116) ↑ Prolymphocytic leukemia (38)

Including sub-types (2019) Tagged with B-cell prolymphocytic leukemia (7)

Trials to join now! 2 Not yet finished but already full! 3 Completed 1 Terminated 1

Experimental lymphoma drug CPO107 tested in small early trial

Disease control Stopped early

This early study tested a new drug called CPO107 in 7 people with advanced CD20-positive Non-Hodgkin lymphoma who had no other good treatment options. The goal was to find a safe dose and see how the body handles the drug. The trial was stopped early, so we have limited informati…

Phase 1 • Sponsor: Conjupro Biotherapeutics, Inc. • Aim: Disease control

Last updated Jun 27, 2026 12:05 UTC

B-cell prolymphocytic leukemia

Where it sits in the disease tree

Experimental lymphoma drug CPO107 tested in small early trial