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Autoimmune polyendocrine syndrome type 1
MONDO:0009411Autoimmune polyendocrinopathy type 1, or APECED syndrome, is a genetic disease that manifests in childhood or early adolescence with a combination of chronic mucocutaneous candidiasis, hypoparathyroidism and autoimmune adrenal failure.
Also known as: AIRE autoimmune polyendocrinopathy, APECED syndrome, APS type 1, APS1, Autoimmune Polyglandular Syndrome Type 1, MEDAC syndrome, Whitaker syndrom, aire autoimmune polyendocrinopathy
48 clinical trials for this condition and its sub-types, 8 tagged with Autoimmune polyendocrine syndrome type 1 itself.
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New hope for rare gut disease? drug trial launches for APECED enteritis
Disease control Recruiting nowThis phase 2 trial tests a drug called emapalumab in 10 people with APECED, a rare disease where the immune system attacks the body. The drug aims to reduce gut inflammation (enteritis) that causes severe symptoms. Participants receive 7 IV doses over 6 months, and researchers tr…
Phase 2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Could a cancer drug regrow hair in rare autoimmune disease?
Disease control Recruiting nowThis phase 2 trial tests whether ruxolitinib, a drug already approved for certain blood disorders, can help regrow hair in people with APECED, a rare immune condition that often causes severe alopecia areata. About 70 participants aged 12 to 75 will take the pill twice daily for …
Phase 2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Scientists launch 25-Year quest to unravel mystery fungal infections
Knowledge-focused Recruiting nowThis study aims to understand why some people get severe or unusual fungal infections due to immune system problems. Researchers will collect blood, tissue, and other samples from up to 1,200 participants over 25 years. No new treatments are being tested; the goal is to learn mor…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC
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Scientists seek clues to fungal infections in immune system study
Knowledge-focused Recruiting nowThis study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC