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Arthrogryposis multiplex congenita

MONDO:0015168

Arthrogryposis multiplex congenita (AMC) is a group of disorders characterized by congenital limb contractures. It manifests as limitation of movement of multiple limb joints at birth that is usually non-progressive and may include muscle weakness and fibrosis. AMC is always associated with decreased intrauterine fetal movement which leads secondarily to the contractures.

Also known as: AMC, Arthromyodysplasia congenita, arthrogryposis multiplex congenita, congenital arthromyodysplasia, multiple congenital arthrogryposis, myodysplasia, Guerin-Stern syndrome, Guérin-Stern syndrome

3 clinical trials for this condition and its sub-types, 1 tagged with Arthrogryposis multiplex congenita itself.

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Where it sits in the disease tree

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↑ Hereditary disease (18187) ↑ Arthrogryposis syndrome (8)

Sub-types of Arthrogryposis multiplex congenita

Arthrogryposis multiplex congenita 2, neurogenic type 0 trials · 1 incl. sub-types
1 sub-type
- Arthrogryposis-renal dysfunction-cholestasis syndrome 1 trial Sub-types →
MYBPC1-related autosomal recessive non-lethal arthrogryposis multiplex congenita syndrome 0 trials
Marden-Walker syndrome 0 trials
Wieacker-Wolff syndrome (spectrum) 0 trials
2 sub-types
- Wieacker-Wolff syndrome 0 trials
- Wieacker-Wolff syndrome, female-restricted 0 trials
Adducted thumbs-arthrogryposis syndrome, Christian type 0 trials
Arthrogryposis due to muscular dystrophy 0 trials
Arthrogryposis multiplex congenita 3, myogenic type 0 trials
Arthrogryposis multiplex congenita 4, neurogenic, with agenesis of the corpus callosum 0 trials
Arthrogryposis multiplex congenita 5 0 trials
Arthrogryposis multiplex congenita 6 0 trials
Arthrogryposis multiplex congenita 7, X-linked 0 trials
Arthrogryposis multiplex congenita-whistling face syndrome 0 trials
Arthrogryposis-hyperkeratosis syndrome, lethal form 0 trials
Arthrogryposis-like syndrome 0 trials
Autosomal recessive myogenic arthrogryposis multiplex congenita 0 trials
Fetal akinesia deformation sequence 0 trials
5 sub-types
- Fetal akinesia deformation sequence 1 0 trials
- Fetal akinesia deformation sequence 2 0 trials
- Fetal akinesia deformation sequence 3 0 trials
- Fetal akinesia deformation sequence 4 0 trials
- Fetal akinesia syndrome, X-linked 0 trials
Hypomyelination neuropathy-arthrogryposis syndrome 0 trials
4 sub-types
- Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect 0 trials
- Lethal congenital contracture syndrome 7 0 trials
- Lethal congenital contracture syndrome 8 0 trials
- Neuropathy, congenital hypomyelinating, 3 0 trials
Infantile-onset X-linked spinal muscular atrophy 0 trials
Lethal arthrogryposis-anterior horn cell disease syndrome 0 trials
Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome 0 trials
Microphthalmia microtia fetal akinesia 0 trials
Multiple pterygium-malignant hyperthermia syndrome 0 trials
Prenatal-onset spinal muscular atrophy with congenital bone fractures 0 trials
2 sub-types
- Spinal muscular atrophy with congenital bone fractures 1 0 trials
- Spinal muscular atrophy with congenital bone fractures 2 0 trials
Van den Ende-Gupta syndrome 0 trials

Most studied deeper sub-types

Arthrogryposis, renal dysfunction, and cholestasis 1 (0) Arthrogryposis, renal dysfunction, and cholestasis 2 (0)

Including sub-types (3) Tagged with Arthrogryposis multiplex congenita (1)

Not yet recruiting 1

Rare pain condition under the microscope: no treatment, just answers

Knowledge-focused Not yet recruiting

This study aims to better understand pain in people with a rare genetic form of arthrogryposis (stiff joints) caused by a PIEZO2 mutation. About 12 participants aged 10 and older will track their pain daily for two weeks using simple questionnaires and body charts. No drugs or tr…

Sponsor: University Hospital, Grenoble • Aim: Knowledge-focused

Last updated Jun 27, 2026 08:13 UTC

Arthrogryposis multiplex congenita

Where it sits in the disease tree

Most studied deeper sub-types

Rare pain condition under the microscope: no treatment, just answers