Arteriovenous malformations of the brain
MONDO:0007154Cerebral arteriovenous malformation (AVM) is a congenital malformative communication between the veins and the arteries in the brain in the form of a nidus, an anatomical structure composed of dilated and tangled supplying arterioles and drainage veins with no intervening capillary bed, that can be asymptomatic or cause, depending on the location and the size of the AVM, headaches of varying severity, generalized or focal seizures, focalneurological defects (weakness, numbness, speech difficulties, vision loss) or potentially fatal intracranial hemorrhage in case the AVM ruptures.
Also known as: arteriovenous malformation of the brain, somatic, arteriovenous malformations of the brain, cerebral arteriovenous malformation, intracranial arteriovenous malformation, intracranial haemorrhage in brain cerebrovascular malformations, susceptibility to, somatic mutation, intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to, somatic mutation, Bavm, cerebral arteriovenous malformations
1469 clinical trials for this condition and its sub-types, 32 tagged with Arteriovenous malformations of the brain itself.
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Brain AVM drug trial pulled before it began
Disease control CancelledThis pilot study aimed to see if the oral drug trametinib could improve the structure of brain arteriovenous malformations (AVMs) in adults before their scheduled surgery. The goal was to shrink the AVM or reduce risky features. However, the trial was withdrawn before enrolling a…
Phase 2 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New laser imaging could help surgeons prevent strokes during brain surgery
Diagnosis PausedThis study tests a laser-based imaging method that shows blood flow in the brain in real time during surgery. It involves 20 adults having brain surgery for conditions like aneurysms. The goal is to see if this technique can give surgeons continuous feedback, unlike the current d…
Sponsor: Andrew Dunn • Aim: Diagnosis
Last updated Jun 27, 2026 13:06 UTC
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Brain procedure may weaken immune defenses, study warns
Knowledge-focused OngoingThis study looks at how a brain procedure called embolization affects the immune system. Researchers will take blood samples from 78 patients before and after the procedure to measure immune markers. They want to understand why patients with brain arteriovenous malformations (AVM…
Sponsor: University Hospital, Limoges • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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New registry aims to unlock secrets of rare bleeding disorder
Knowledge-focused OngoingThis study is creating a registry of people with Hereditary Hemorrhagic Telangiectasia (HHT), a rare condition that causes abnormal blood vessels and frequent nosebleeds. Researchers will collect health information from about 1,000 adults over many years to see how the disease ch…
Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC