APP-related brain and vascular amyloidosis

MONDO:1060190

A hereditary amyloidosis characterized by a spectrum of neurodegenerative and neurovascular phenotypes caused by pathogenic variant in the APP gene, resulting in an abnormal clearance of amyloid peptides, either by overproduction and decreased clearance of amyloid peptides, with deposition of amyloid in plaques and blood vessel walls. Affected individuals may present with progressive cognitive decline, cerebral vascular amyloidosis with white matter changes, and stroke with or without hemorrhage.

Also known as: APP-related brain and vascular amyloidosis

18 clinical trials for this condition and its sub-types, 0 tagged with APP-related brain and vascular amyloidosis itself.

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Where it sits in the disease tree

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↑ Cerebrovascular disorder (3292) ↑ Inherited neurodegenerative disorder (808) ↑ Hereditary amyloidosis (79)

Sub-types of APP-related brain and vascular amyloidosis

Alzheimer disease type 1 4 trials
Cerebral amyloid angiopathy, APP-related 0 trials · 1 incl. sub-types
6 sub-types
- ABeta amyloidosis, dutch type 1 trial
- ABeta amyloidosis, Arctic type 0 trials
- ABeta amyloidosis, Iowa type 0 trials
- ABeta amyloidosis, Italian type 0 trials
- ABetaA21G amyloidosis 0 trials
- ABetaL34V amyloidosis 0 trials

Including sub-types (18) Tagged with APP-related brain and vascular amyloidosis (0)

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