Aortic valve disease 1
MONDO:0024523Any aortic valve disease in which the cause of the disease is a mutation in the NOTCH1 gene.
Also known as: AOVD1, NOTCH1 aortic valve disease, Notch1 aortic valve disease, aortic valve disease 1, aortic valve disease caused by mutation in NOTCH1, aortic valve disease caused by mutation in Notch1, aortic stenosis, calcific, aortic valve disease
147 clinical trials for this condition and its sub-types, 16 tagged with Aortic valve disease 1 itself.
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New hope for heart valve patients: less invasive procedure tested
Disease control OngoingThis study is testing a less invasive procedure called TAVR to replace the aortic valve in 150 people who have a bicuspid aortic valve (a valve with two flaps instead of three) and severe narrowing. The goal is to see if it is safe and works well for people who are at low risk fo…
Sponsor: Medtronic Cardiovascular • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Less invasive heart valve fix could rival Open-Heart surgery for tough cases
Disease control By invitation onlyThis study compares two ways to replace a narrowed heart valve in people with a bicuspid aortic valve (a common birth defect). One method is transcatheter aortic valve replacement (TAVR), a less invasive procedure using a tube inserted through a blood vessel. The other is traditi…
Sponsor: Shanghai MicroPort CardioFlow Medtech Co., Ltd. • Aim: Disease control
Last updated Jun 26, 2026 18:14 UTC
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11,000 volunteers help unlock genetic secrets of heart valve disease
Knowledge-focused OngoingThis study is looking for the genetic causes of bicuspid aortic valve disease, a common heart condition where the aortic valve has two flaps instead of three. Researchers will analyze DNA from 11,000 participants, including patients and their relatives, to find gene changes linke…
Sponsor: Boston University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Scientists hunt for hidden genes behind aortic aneurysms
Knowledge-focused OngoingThis study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC