Aortic valve disease 1
MONDO:0024523Any aortic valve disease in which the cause of the disease is a mutation in the NOTCH1 gene.
Also known as: AOVD1, NOTCH1 aortic valve disease, Notch1 aortic valve disease, aortic valve disease 1, aortic valve disease caused by mutation in NOTCH1, aortic valve disease caused by mutation in Notch1, aortic stenosis, calcific, aortic valve disease
147 clinical trials for this condition and its sub-types, 16 tagged with Aortic valve disease 1 itself.
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AI may spot dangerous aortic growth before it happens
Knowledge-focused CompletedThis study is testing whether an artificial intelligence model can predict how the aorta might dilate (widen) in people with bicuspid aortic valve—a common heart valve condition that raises the risk of aortic aneurysm. Researchers will analyze CT scans from 1,000 patients who had…
Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC
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A new way to size heart valves: could the 'circle method' reduce TAVI complications?
Knowledge-focused CompletedThis study looks at whether the 'circle method' — a way to measure the aortic valve — can help doctors choose the right size replacement valve for people with bicuspid aortic valves who are getting a TAVI procedure. Researchers will review past cases to see if patients whose valv…
Sponsor: Institut für Pharmakologie und Präventive Medizin • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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New study tracks how a common heart valve performs in people born with a bicuspid valve
Knowledge-focused CompletedThis study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…
Sponsor: Clinique Pasteur • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Scientists hunt for genetic clues to aortic aneurysm risk
Knowledge-focused CompletedThis study collected blood and tissue samples from 91 adults with aortic valve disease to look for genetic differences that might explain why some develop aortic aneurysms. Researchers compared gene activity in people with bicuspid valves, tricuspid valves, and healthy controls. …
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC