Antisynthetase syndrome

MONDO:0019344

Antisynthetase (AS) syndrome is a clinically heterogeneous form of idiopathic inflammatory myopathy characterized by myositis, arthralgia, Raynaud phenomenon, mechanic hands, interstitial lung disease (ILD), and serum autoantibodies to aminoacyl transfer RNA synthetases (anti-ARS).

Also known as: AS syndrome, anti-Jo1 syndrome

28 clinical trials for this condition and its sub-types, 21 tagged with Antisynthetase syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Acquired idiopathic inflammatory myopathy (159)

Including sub-types (28) Tagged with Antisynthetase syndrome (21)

Trials to join now! 10 Not yet recruiting 2 Not yet finished but already full! 3 Completed 5 Terminated 1

Lung disease drug tested in rare muscle condition – trial cut short

Disease control Stopped early

This study tested the drug nintedanib (Ofev) in 11 people with myositis-related interstitial lung disease, a condition where lung scarring occurs alongside muscle inflammation. The goal was to see if the drug is safe and tolerable when added to standard immune-suppressing treatme…

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre • Aim: Disease control

Last updated Jun 26, 2026 13:17 UTC

Antisynthetase syndrome

Where it sits in the disease tree

Lung disease drug tested in rare muscle condition – trial cut short