Anti-MDA5 dermatomyositis

MONDO:1010064

A dermatomyositis characterized by the presence of anti-MDA5 autoantibodies. It is often associated with dermatomyositis rashes, amyopathic or hypomyopathic muscle involvement and interstitial lung disease, frequently as a rapid progressive course and high mortality.

Also known as: MDA-5 DM, MDA5+ DM, anti-melanoma differentiation-associated gene 5 dermatomyositis, clinically amyopathic dermatomyositis

15 clinical trials for this condition and its sub-types, 3 tagged with Anti-MDA5 dermatomyositis itself.

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Where it sits in the disease tree

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Including sub-types (15) Tagged with Anti-MDA5 dermatomyositis (3)

Trials to join now! 2 Not yet recruiting 1

Promising drug could save lives in rare, deadly lung disease

Disease control Not yet recruiting

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

Phase 2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control

Last updated Jun 27, 2026 13:02 UTC

Anti-MDA5 dermatomyositis

Where it sits in the disease tree

Promising drug could save lives in rare, deadly lung disease