Anal squamous cell carcinoma
MONDO:0006082A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC.
Also known as: anal squamous cell cancer, anal squamous cell carcinoma, anus squamous cell carcinoma, epidermoid anal carcinoma, epidermoid carcinoma of anus, epidermoid carcinoma of the anus, squamous cell anal carcinoma, squamous cell carcinoma - anus
2938 clinical trials for this condition and its sub-types, 40 tagged with Anal squamous cell carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Anal squamous cell carcinoma
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Anal canal squamous cell carcinoma 12 trials
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Anal margin squamous cell carcinoma 4 trials
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Anus basaloid carcinoma 3 trials
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Anal verrucous carcinoma 0 trials
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New drug combo targets Hard-to-Treat cancers
Disease control Stopped earlyThis early-phase study tests an experimental drug called INCB177054, given alone or with another drug (retifanlimab), in people with advanced or metastatic solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose. Abo…
Phase 1/2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Experimental drug targets Hard-to-Treat cancers, but trial ends early
Disease control Stopped earlyThis study tested an experimental drug called vobramitamab duocarmazine in people with advanced prostate cancer and other solid tumors that stopped responding to standard treatments. The goal was to see if the drug could shrink tumors or slow cancer growth. The trial was terminat…
Phase 2 • Sponsor: MacroGenics • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC