Alzheimer disease 4
MONDO:0011743Alzheimer's disease with an early onset (starts before the age of 65). It is caused by mutations in the PSEN2 gene.
Also known as: AD4, Alzheimer disease 4, Alzheimer disease type 4, Alzheimer disease-4, Alzheimer's disease 4, Alzheimer's disease type 4, familial Alzheimer disease, type 4, familial Alzheimer's disease, type 4
6 clinical trials for this condition and its sub-types, 3 tagged with Alzheimer disease 4 itself.
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Experimental Alzheimer's drug aims to quiet Brain's toxic tau
Disease control Recruiting nowThis early-stage trial tests a drug called NIO752, given via spinal injection, to see if it can reduce production of tau protein in the brain. Tau buildup is linked to Alzheimer's damage. Ten people with mild to moderate Alzheimer's will receive either NIO752 or a placebo, and re…
Phase 1 • Sponsor: University College, London • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Can a simple test predict Alzheimer's years before symptoms start?
Knowledge-focused Recruiting nowThis long-term study follows 700 adults who carry a rare genetic mutation that causes early-onset Alzheimer's. Researchers collect blood, spinal fluid, brain scans, and cognitive tests to find biomarkers that signal the disease before memory loss begins. The goal is to improve ea…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jul 22, 2026 00:00 UTC