Alpha-heavy chain disease

MONDO:0015045

Alpha-heavy chain disease (alpha-HCD) is a type of HCD characterized by the production of incomplete monoclonal alpha-heavy chains without associated light chains. Alpha-HCD is considered to be a subtype of immunoproliferative small intestinal disease (IPSID). The clinical presentation includes chronic diarrhea with evidence of malabsorption.

Also known as: Alpha heavy chain disease, Alpha-HCD, IPSID, Immunoproliferative small intestinal disease, Mediterranean abdominal lymphoma, Mediterranean lymphoma, Mediterraneanl lymphoma, alpha chain disease

1931 clinical trials for this condition and its sub-types, 1 tagged with Alpha-heavy chain disease itself.

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Where it sits in the disease tree

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↑ Heavy chain disease (2)

Including sub-types (1931) Tagged with Alpha-heavy chain disease (1)

Trials to join now! 1

Could a simple injection dissolve painful calcium lumps in rare diseases?

Disease control Recruiting now

This study tests whether injecting sodium thiosulfate directly into abnormal calcium deposits can shrink them and reduce pain. It includes people with three rare conditions: systemic sclerosis, dermatomyositis, and a genetic disorder called iPPSD2. Participants receive up to 11 i…

Phase 2 • Sponsor: University Hospital, Limoges • Aim: Disease control

Last updated Sep 17, 2026 00:00 UTC

Alpha-heavy chain disease

Where it sits in the disease tree

Could a simple injection dissolve painful calcium lumps in rare diseases?