ALK-positive large B-cell lymphoma

Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a very rare variant of diffuse large B-cell lymphoma (DLBCL) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis.

Also known as: ALK+ LBCL, ALK+ large B-cell lymphoma, ALK-DLBCL, ALK-positive large B-cell lymphoma, diffuse large B-cell lymphoma with expression of full-length ALK, diffuse large B-cell lymphoma with expression of full-length anaplastic lymphoma kinase

2003 clinical trials for this condition and its sub-types, 5 tagged with ALK-positive large B-cell lymphoma itself.