Alcoholic hepatitis

This phase 3 trial compares two steroid schedules for severe alcohol-associated hepatitis, a serious liver condition with high death rates. One group takes prednisolone for 7 days followed by a placebo for 7 days, while the other takes prednisolone for the full 14 days. Researche…

This pilot study tests whether a coordinated care program can help people with alcohol-related liver disease access addiction and mental health services more easily. The program brings together liver specialists, addiction medicine, and psychiatry to streamline referrals and care…

This study tested an experimental drug called ADX-629 in 4 adults with moderate alcohol-related hepatitis. The goal was to see if the drug is safe and can help control liver inflammation. Participants had to stop drinking alcohol during the trial. The study is now complete, and r…

This phase 3 trial tested whether a single injection of radioactive lipiodol (Lipiocis) into the liver artery could prevent hepatocellular carcinoma from coming back after surgery or ablation. The study enrolled 73 adults with cirrhosis and one or two liver tumors that had been s…

This early-stage trial tested a device called miroliverELAP, which uses a bioengineered liver graft to filter blood outside the body, in 10 adults with acute liver failure. The goal was to check safety and see if it can support the liver for up to 48 hours, giving time for recove…

This study looked at whether early liver transplantation can help people with severe alcoholic hepatitis who did not get better with medical treatment. Researchers compared alcohol relapse rates in 284 patients who received early transplants to those transplanted after a 6-month …

This study tested whether adding an antibiotic (amoxicillin-clavulanic acid) to the usual steroid treatment could improve survival in people with severe alcoholic hepatitis. About 300 adults at high risk of death within two months took part. The goal was to see if the antibiotic,…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…

This study looked at over 5,000 adults in Zambia to find out how many have hepatitis B and how many need treatment. Researchers tested people in their homes and then did more tests on those who tested positive. The goal was to gather information, not to test a new treatment or cu…