Agammaglobulinemia

MONDO:0015977

A decreased level of serum immunoglobulins. It may be inherited or acquired. It is caused by decreased or inefficient production of immunoglobulins from B cells or by a decrease in the numbers of B cells themselves. Low levels of immunoglobulins will affect the immune system's ability to combat bacterial infection. Supplementation of immunoglobulins is needed to prevent worsening outcomes.

Also known as: agammaglobulinemia, Gammaglobulin Deficiency, Immunoglobulin Deficiency, antibody Deficiency

85 clinical trials for this condition and its sub-types, 16 tagged with Agammaglobulinemia itself.

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Where it sits in the disease tree

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Part of

↑ B cell deficiency (86)

Sub-types of Agammaglobulinemia

Syndromic agammaglobulinemia 7 trials · 37 incl. sub-types
3 sub-types
- Common variable immunodeficiency 29 trials · 31 incl. sub-types Sub-types →
- Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome 0 trials
- Transient hypogammaglobulinemia 0 trials Sub-types →
Activated PI3K-delta syndrome 5 trials · 6 incl. sub-types
2 sub-types
- Immunodeficiency 14 6 trials
- Immunodeficiency 36 with lymphoproliferation 0 trials
Isolated agammaglobulinemia 0 trials · 4 incl. sub-types
2 sub-types
- Bruton-type agammaglobulinemia 4 trials
- Autosomal agammaglobulinemia 1 trial Sub-types →
Good syndrome 0 trials
Agammaglobulinemia 10, autosomal dominant 0 trials
Agammaglobulinemia 8b, autosomal recessive 0 trials
Agammaglobulinemia 9, autosomal recessive 0 trials
Agammaglobulinemia, autosomal recessive, due to BOB1 deficiency 0 trials
Congenital agammaglobulinemia 0 trials
2 sub-types
- Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome 0 trials
- Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia 0 trials
Immunodeficiency 61 0 trials

Most studied deeper sub-types

Immunodeficiency, common variable, 12 (1) Pancytopenia due to IKZF1 mutations (1) Agammaglobulinemia 2, autosomal recessive (0) Agammaglobulinemia 3, autosomal recessive (0) Agammaglobulinemia 4, autosomal recessive (0) Agammaglobulinemia 5, autosomal dominant (0) Agammaglobulinemia 6, autosomal recessive (0) Agammaglobulinemia 7, autosomal recessive (0) Agammaglobulinemia 8, autosomal dominant (0) Autosomal recessive agammaglobulinemia 1 (0) Combined immunodeficiency due to LRBA deficiency (0) Deficiency in anterior pituitary function - variable immunodeficiency syndrome (0) IL21-related infantile inflammatory bowel disease (0) Immune deficiency, familial variable (0) Immunodeficiency, common variable, 1 (0) Immunodeficiency, common variable, 10 (0) Immunodeficiency, common variable, 14 (0) Immunodeficiency, common variable, 15 (0) Immunodeficiency, common variable, 2 (0) Immunodeficiency, common variable, 3 (0)

Including sub-types (85) Tagged with Agammaglobulinemia (16)

Trials to join now! 9 Not yet finished but already full! 2 Completed 5

Agammaglobulinemia

Where it sits in the disease tree

Most studied deeper sub-types

Rewriting the code: a One-Time gene fix for a rare immune disease?

New antibody therapy aims to shield kids with rare immune disease from deadly infections