Adult-onset Still disease
MONDO:0019355A rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.
Also known as: AOSD, Adult-Onset Still's Disease, Wissler-Fanconi syndrome, adult-onset Still disease, adult-onset Still's disease, Still's disease adult onset, adult Still's disease
46 clinical trials for this condition and its sub-types, 12 tagged with Adult-onset Still disease itself.
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New drug aims to calm dangerous immune storms in Still's and lupus patients
Disease control CompletedThis study tested a drug called emapalumab in 33 children and adults with macrophage activation syndrome (MAS), a life-threatening immune overreaction, linked to Still's disease or lupus. The goal was to see if the drug could safely control the condition and reduce the need for h…
Phase 3 • Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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New biologic shows promise for rare inflammatory disease in japan
Disease control CompletedThis study tested canakinumab, an anti-inflammatory biologic, in 14 Japanese adults with Adult-Onset Still's Disease (AOSD), a rare condition causing fevers and joint pain. Participants received injections every 4 weeks for at least 48 weeks. The goal was to see if the drug could…
Phase 3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Researchers dig into patient histories to uncover clues about macrophage activation syndrome
Knowledge-focused CompletedThis completed study reviewed the medical charts of 32 people with Still's disease who developed a serious complication called macrophage activation syndrome (MAS). The goal was to learn more about their symptoms, how long it took for lab values to return to normal, and what trea…
Sponsor: Swedish Orphan Biovitrum • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC