Adrenal cortex carcinoma
MONDO:0006639A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells. Symptoms are usually related to the excessive production of hormones, and include Cushing's syndrome and virilism in women. Common sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced radiologic procedures have enabled the detection of small tumors, resulting in the improvement of the 5-year survival.
Also known as: adrenal cortex cancer, adrenal cortical tumors, adrenal cortical tumours, adrenocortical cancer, cancer of the adrenal cortex, malignant adrenocortical tumor, malignant adrenocortical tumour, malignant neoplasm of adrenal cortex
2825 clinical trials for this condition and its sub-types, 42 tagged with Adrenal cortex carcinoma itself.
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Sub-types of Adrenal cortex carcinoma
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Adrenocortical carcinoma, hereditary 0 trials
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Liver tumors targeted directly: old pump, new drug
Disease control Not yet recruitingThis trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 21, 2026 18:00 UTC
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Can a new drug shrink Hard-to-Treat adrenal tumors?
Disease control Not yet recruitingThis phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Radiation after surgery may keep rare adrenal cancer at bay
Disease control Not yet recruitingThis study looks at whether giving radiation therapy after surgery can help prevent high-risk adrenocortical carcinoma from coming back. Fifty-eight patients who had their tumor completely removed will be randomly assigned to either receive radiation or just be monitored. The mai…
Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 26, 2026 12:56 UTC