Active tuberculosis
MONDO:0100481Tuberculosis caused by primary infection of or reactivation of latent Mycobacterium tuberculosis. Active tuberculosis characterized by clinical manifestation and active symptoms compatible with tuberculosis, and is distinct from latent tuberculosis infection that occurs without signs or symptoms of active disease.
Also known as: active TB
29 clinical trials for this condition and its sub-types, 23 tagged with Active tuberculosis itself.
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Could a simple blood test revolutionize dormant TB detection?
Diagnosis By invitation onlyThis study evaluates a new blood test that aims to directly detect the bacteria causing dormant tuberculosis (TB), rather than relying on the body's immune response. Current tests cannot tell if treatment worked or who will develop active TB, leading to unnecessary antibiotics. R…
Sponsor: Queen Mary University of London • Aim: Diagnosis
Last updated Jun 27, 2026 09:07 UTC
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Four weeks vs twelve weeks: can a shorter TB prevention course work?
Prevention OngoingResearchers are testing whether a 4-week daily course of isoniazid and rifapentine can prevent active tuberculosis as well as the standard 12-week weekly course in people with HIV who have latent TB infection. The trial enrolls about 2,500 adults in a high TB burden country. Both…
Phase 3 • Sponsor: The HIV Netherlands Australia Thailand Research Collaboration • Aim: Prevention
Last updated Sep 18, 2026 00:00 UTC
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Can a One-Month TB prevention course beat the standard Three-Month regimen?
Prevention CancelledTuberculosis infection can progress to active, contagious TB disease, but preventive treatment often lasts three to nine months and many people do not finish it. This Phase 3 trial in Hanoi, Vietnam, compares a new one-month regimen of daily isoniazid and rifapentine with the sta…
Phase 3 • Sponsor: Freundeskreis Für Internationale Tuberkulosehilfe e.V • Aim: Prevention
Last updated Sep 11, 2026 00:00 UTC
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Could a One-Month TB pill be as good as three? new trial tests shorter prevention
Prevention OngoingThis study tests whether taking two TB prevention drugs daily for one month works as well as taking them weekly for three months. It includes 1,000 people with HIV or those living with someone recently diagnosed with TB. The goal is to see which schedule more people complete and …
Phase 4 • Sponsor: The Aurum Institute NPC • Aim: Prevention
Last updated Jun 27, 2026 08:03 UTC
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New study tracks TB drugs in breastmilk to protect infants
Knowledge-focused OngoingThis study looks at how tuberculosis (TB) medications travel through a mother's body, into her breastmilk, and to her nursing baby. Researchers will take blood and milk samples from 20 mothers and small blood samples from their infants at several time points after a dose. The goa…
Sponsor: University of Liverpool • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC