ACTH-dependent Cushing syndrome

MONDO:0020528

A group of endogenous Cushing syndrome caused by abnormal production of ACTH due to pituitary adenoma or an extrapituitary tumor.

Also known as: ACTH-dependent CS, adrenocorticotropic hormone-dependent Cushing syndrome, corticotropin-dependent Cushing syndrome, pituitary-dependent Cushing's disease, ACTH hypersecretion, pituitary, adrenocorticotropic hormone, inappropriate secretion, pituitary Cushing disease, pituitary Cushing diseases

29 clinical trials for this condition and its sub-types, 23 tagged with ACTH-dependent Cushing syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Hyperpituitarism (59) ↑ Endogenous Cushing syndrome (38)

Sub-types of ACTH-dependent Cushing syndrome

Cushing disease due to pituitary adenoma 23 trials
Ectopic Cushing syndrome 1 trial

Including sub-types (29) Tagged with ACTH-dependent Cushing syndrome (23)

Trials to join now! 12 Not yet recruiting 1 Not yet finished but already full! 6 Completed 4

Can a stronger radiation dose fix hormone overload?

Disease control Not yet recruiting

Researchers are testing whether a higher dose of proton beam therapy can normalise hormone levels better than standard radiotherapy in people with functioning pituitary tumours, including acromegaly and Cushing's disease. Participants receive about six weeks of either standard-do…

Phase 3 • Sponsor: University College, London • Aim: Disease control

Last updated Sep 12, 2026 00:00 UTC

ACTH-dependent Cushing syndrome

Where it sits in the disease tree

Can a stronger radiation dose fix hormone overload?