Acquired idiopathic inflammatory myopathy
MONDO:0020122An umbrella term for diseases which have chronic muscle inflammation and weakness of unknown etiology. The types of idiopathic inflammatory myopathy are further defined by either clinicopathologic criteria or by the presence of certain autoantibodies.
Also known as: IIm, IMM, idiopathic inflammatory myopathies, idiopathic inflammatory myositis, idiopathic inflammatory myopathy, familial
160 clinical trials for this condition and its sub-types, 67 tagged with Acquired idiopathic inflammatory myopathy itself.
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Sub-types of Acquired idiopathic inflammatory myopathy
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Polymyositis 36 trials · 100 incl. sub-types
2 sub-types
- Dermatomyositis 81 trials · 100 incl. sub-types Sub-types →
- Juvenile polymyositis 3 trials
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Juvenile idiopathic inflammatory myopathy 2 trials · 42 incl. sub-types
3 sub-types
- Juvenile dermatomyositis 41 trials
- Juvenile polymyositis 3 trials
- Juvenile overlap myositis 0 trials
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Antisynthetase syndrome 21 trials
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Immune-mediated necrotizing myopathy 17 trials
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Overlap myositis 2 trials
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Eosinophilic fasciitis 1 trial
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Focal myositis 0 trials
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Idiopathic eosinophilic myositis 0 trials
Most studied deeper sub-types
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New drug shows promise for rare muscle disease
Disease control CompletedThis study tested an experimental drug called daxdilimab in 12 adults with dermatomyositis or anti-synthetase myositis that wasn't well controlled by standard treatments. The goal was to see if the drug could reduce disease activity and skin symptoms, and help lower steroid use o…
Phase 2 • Sponsor: Amgen • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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Can a targeted immune drug calm rare muscle inflammation?
Disease control CompletedThis trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …
Phase 2/3 • Sponsor: argenx • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Robotic leg device shows promise for helping muscle disease patients walk
Symptom relief CompletedThis study tested a powered leg exoskeleton (Keeogo) in 50 people with various muscle disorders to see if it is safe and helps them walk better. Participants performed walking tests with and without the device. The goal was to see if the device could improve walking distance and …
Sponsor: Institut de Myologie, France • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Robotic exoskeleton shows promise for muscle disease patients
Symptom relief CompletedThis study tested a wearable robotic suit called MyoSuit that assists knee and hip movement in people with various muscle disorders. 32 participants used the device to perform walking tests, and researchers checked for safety and any immediate improvements in walking ability. The…
Sponsor: Institut de Myologie, France • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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COVID-19's hidden toll on autoimmune patients revealed
Knowledge-focused CompletedThis study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Twin study seeks clues to rheumatic disease mysteries
Knowledge-focused CompletedThis study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…
Sponsor: National Institute of Environmental Health Sciences (NIEHS) • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Scientists hunt for genetic and environmental triggers of rare muscle diseases
Knowledge-focused CompletedThis study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …
Sponsor: National Institute of Environmental Health Sciences (NIEHS) • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC