Acquired aplastic anemia

Researchers are testing a conditioning regimen built around thiotepa before a haploidentical, or half-matched, stem cell transplant in people aged 50 and older with severe aplastic anemia. The regimen also includes busulfan, fludarabine, anti-thymocyte globulin, and basiliximab, …

This trial tests a combination of sirolimus, ruxolitinib, and mycophenolate mofetil to prevent acute graft-versus-host disease (aGVHD) in patients receiving a half-matched stem cell transplant. The study focuses on patients with blood cancers or severe aplastic anemia who cannot …

This study tests an experimental drug called dibotatug (DR-01) in adults with bone marrow failure syndromes, including severe aplastic anemia. The goal is to see if the drug is safe and can improve blood cell counts. Participants receive dibotatug by IV infusion, and researchers …

This phase 2 trial tests a combination of three drugs—cyclosporine, a thrombopoietin receptor agonist (eltrombopag or hetrombopag), and romiplostim—in 43 adults newly diagnosed with severe aplastic anemia or transfusion-dependent non-severe aplastic anemia. The goal is to see if …

This study tests a new drug called golidocitinib, combined with strong immune-suppressing therapy, for people with severe aplastic anemia—a condition where the bone marrow stops making enough blood cells. The trial has two parts: first, it checks safety in patients who didn't imp…

This study will look at the medical records of 35 children aged 1 to 18 who have acquired aplastic anemia, a rare condition where the bone marrow stops making enough blood cells. Researchers want to learn about the symptoms, possible causes, and how the disease is managed in Assi…