Acanthosis nigricans
MONDO:0007035A melanotic cutaneous lesion that develops in the axilla and other body folds. It may be idiopathic, drug-induced, or it may be associated with the presence of an endocrine disorder or malignancy.
Also known as: acanthosis nigricans, acanthosis nigricans (disease), an - acanthosis nigricans
5 clinical trials for this condition and its sub-types, 4 tagged with Acanthosis nigricans itself.
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Sub-types of Acanthosis nigricans
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Familial acanthosis nigricans 0 trials
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Can a skin cream replace a diabetes drug for dark patches?
Disease control CompletedThis trial tests three ways to treat acanthosis nigricans, a skin condition causing dark, thick patches often linked to insulin resistance and obesity. About 54 people with the condition will receive either oral metformin, a topical metformin cream, or a glycolic acid chemical pe…
Sponsor: Tanta University • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Chromium picolinate shows promise for teen skin condition linked to insulin resistance
Disease control CompletedThis study tested whether taking chromium picolinate daily for 24 weeks could reduce the severity of acanthosis nigricans (dark, thick skin patches) and improve insulin resistance in adolescents aged 12 to 18. Researchers compared the supplement to a placebo in 90 participants. T…
Sponsor: Uruk University • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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New gel shows promise for dark skin patches
Symptom relief CompletedThis small study tested a gel containing sirolimus (0.2%) on 5 adults with acanthosis nigricans, a condition causing dark, thick skin patches. The goal was to see if the gel safely lightens the skin and improves texture over 12 weeks. Researchers measured changes in skin color an…
Phase 2 • Sponsor: Narrows Institute for Biomedical Research • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC