Acantholytic squamous cell skin carcinoma

MONDO:0004316

A histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis.

Also known as: acantholytic squamous cell carcinoma of the skin, acantholytic squamous cell skin carcinoma, acantholytic squamous cell carcinoma of skin

2776 clinical trials for this condition and its sub-types, 1 tagged with Acantholytic squamous cell skin carcinoma itself.

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Where it sits in the disease tree

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Part of

↑ Skin squamous cell carcinoma (158) ↑ Keratinizing squamous cell carcinoma (1)

Including sub-types (2776) Tagged with Acantholytic squamous cell skin carcinoma (1)

Not yet finished but already full! 1

Could a Pre-Surgery immune booster beat standard care for skin cancer?

Disease control Paused

This phase III trial compares adding the immunotherapy drug cemiplimab before surgery (with or without radiation) to standard surgery alone for people with stage III/IV squamous cell skin cancer that can be removed. The goal is to see if the combination improves event-free surviv…

Phase 3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Sep 03, 2026 00:00 UTC

Acantholytic squamous cell skin carcinoma

Where it sits in the disease tree

Could a Pre-Surgery immune booster beat standard care for skin cancer?