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Up to: Syndromic disease · Hereditary hyperbilirubinemia
Crigler-Najjar syndrome
Crigler-Najjar syndrome (CNS) is a hereditary disorder of bilirubin metabolism characterized by unconjugated hyperbilirubinemia due to a hepatic deficit of bilirubin glucuronosyltransferase (GT) activity. Two types have been described, CNS types 1 and 2. CNS1 is characterized by a complete deficit of the enzyme and is unaffected by phenobarbital induction therapy, whereas the enzymatic deficit is partial and responds to phenobarbital in CNS2.
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Crigler-Najjar syndrome type 1 0 trials
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Crigler-Najjar syndrome type 2 0 trials