Browse
Explore conditions, clinical trials, and the organisations running them.
Up to: Classic complement early component deficiency · Immunodeficiency due to a classical component pathway complement deficiency
Complement component C1r/C1s deficiency
Lack of production of either functional C1r or C1s protein, due to a genetic defect. Approximately 60% of patients with a C1r/C1s deficiency will develop a severe systemic lupus erythematosus at an early age. Patients also present with frequent sinopulmonary infections often with Streptococcus pneumoniae.
This condition has no sub-types.