Browse
Explore conditions, clinical trials, and the organisations running them.
Up to: High grade astrocytic tumor
Glioblastoma
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)
-
Brain glioblastoma 24 trials · 87 incl. sub-types Sub-types →
-
IDH-wildtype glioblastoma 82 trials
-
Adult glioblastoma 25 trials Sub-types →
-
Classical glioblastoma 3 trials
-
Mesenchymal glioblastoma 0 trials
-
Neural glioblastoma 0 trials
-
Proneural glioblastoma 0 trials