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Up to: Syndromic dyslipidemia · Disorder of phospholipids, sphingolipids and fatty acids biosynthesis · Neurodegeneration with brain iron accumulation · Complex hereditary spastic paraplegia

Fatty acid hydroxylase-associated neurodegeneration

Fatty acid hydroxylase-associated neurodegeneration (FAHN) is a very rare, autosomal recessive form of neurodegeneration with brain iron accumulation (NBIA) characterized by childhood-onset focal dystonia, progressive spastic paraplegia that progresses to tetra paresis, ataxia, dysarthria, intellectual decline, and oculomotor disturbances (optic atrophy), accompanied by iron deposition in the globus pallidus.

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