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Up to: Developmental anomaly of metabolic origin · Multiple congenital anomalies/dysmorphic syndrome without intellectual disability · Hereditary lipodystrophy · Primary osteolysis
Mandibuloacral dysplasia
Mandibuloacral dysplasia (MAD) is a rare genetic bone disorder characterized by growth delay, postnatal development of craniofacial anomalies including mandibular hypoplasia, progressive acral osteolysis, mottled or patchy pigmentation, skin atrophy, and partial or generalized lipodystrophy.