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Severe combined immunodeficiency

Severe combined immunodeficiency (SCID) comprises a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes resulting in early-onset severe respiratory infections and failure to thrive. They are classified according to immunological phenotype into SCID with absence of T cells but presence of B cells (T-B+ SCID) or SCID with absence of both (T-B- SCID). Both of these groups include several forms, with or without natural killer (NK) cells.

24 trials tagged with this condition →

Familial severe combined immunodeficiency 0 trials · 22 incl. sub-types Sub-types →
T-B- severe combined immunodeficiency 0 trials · 14 incl. sub-types Sub-types →
T-B+ severe combined immunodeficiency 0 trials · 10 incl. sub-types Sub-types →
T+ B+ severe combined immunodeficiency 0 trials Sub-types →
T-cell immunodeficiency, congenital alopecia, and nail dystrophy 0 trials
Immunodeficiency 79 0 trials
Janus kinase-3 deficiency 0 trials
Recombinase activating gene 1 deficiency 0 trials
Recombinase activating gene 2 deficiency 0 trials
Severe combined immunodeficiency due to CARMIL2 deficiency 0 trials
Severe combined immunodeficiency due to CD70 deficiency 0 trials