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Up to: Autosomal recessive syndromic cerebellar ataxia · Peroxisome biogenesis disorder due to PEX6 defect

Peroxisome biogenesis disorder 4B

Any peroxisome biogenesis disorder due to PEX6 defect characterized by the association of early-onset cerebellar ataxia with hearing loss and blindness. Patients may also present demyelinating peripheral motor neuropathy. Cerebral MRI shows alterations of the cerebellar white matter without cerebellar atrophy.

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