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Up to: Combined oxidative phosphorylation deficiency

Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency

A rare mitochondrial oxidative phosphorylation disorder with complex I and IV deficiency characterized by lactic acidosis, hypotonia, hypertrophic cardiomyopathy and global developmental delay. Other clinical features include feeding difficulties, failure to thrive, seizures, optic atrophy and ataxia.

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