Browse
Explore conditions, clinical trials, and the organisations running them.
Up to: Complex hereditary spastic paraplegia
Hereditary spastic paraplegia 45
Autosomal recessive spastic paraplegia type 45 is a rare, pure or complex form of hereditary spastic paraplegia characterized by onset in infancy of progressive lower limb spasticity, abnormal gait, increased deep tendon reflexes and extensor plantar responses, that may be associated with intellectual disability. Additional signs, such as contractures in the lower limbs, amyotrophy, clubfoot and optic atrophy, have also been reported.
This condition has no sub-types.