Browse
Explore conditions, clinical trials, and the organisations running them.
Up to: Congenital nervous system disorder · Myofibrillar myopathy · Autosomal dominant distal myopathy · Qualitative or quantitative defects of protein ZASP
Myofibrillar myopathy 4
Late-onset distal myopathy, Markesbery-Griggs type is a rare, genetic, non-dystrophic myofibrillar myopathy disorder characterized by late-adult onset of distal and/or proximal limb muscle weakness with initial involvement of posterior lower leg muscles, medial gastrocnemius and soleus. Patients present with ankle weakness followed by weakness of finger and wrist extensors and later on of proximal muscles. Ambulation is usually preserved. Late-onset associated cardiomyopathy and/or neuropathy has been reported in a minority of cases.
This condition has no sub-types.